New comments cannot be posted and votes cannot be cast. Ideally, one shouldn't ever have to up the dose. Energy yes, no focus or concentration, and it just masked the exhaustion. Answer. What is your experience with the duration of Vyvanse? The site may not work properly if you don't, If you do not update your browser, we suggest you visit, Press J to jump to the feed. Press J to jump to the feed. Vyvanse® (lisdexamfetamine dimesylate) improved attention throughout the day for each time point tested, starting at 2 hours and even at 14 hours after taking it. Was moved up to 40mg from 30, after a month or two the duration wore off. The duration of effects for Vyvanse is about 10–13 hours, though some studies report it is up to 14 hours. The crash happened to me when I first started it but after two weeks it wasn't a crash but can tell when it is wearing off. However, most patients report they experience the effects of this medication for only around 8 hours. My doctor was very understanding when I described my concerns. I take it around 9 am and it's been lasting until maybe 5 or a little earlier. Either way, it's been good for me and I'm going to talk to my psych next month about going up in dose a bit. I have been taking Vyvanse for a few years and it seems to not be lasting as long. Vyvanse - How fast does your tolerance build up, how do you recognize the signs & cope with it? Aside from weird effects combining with the meds themselves, it gives me a very rapid resting heart rate (north of 120 beats/minute after sitting for 10+ minutes) and heart palpitations. I also have depression but my ad doesn't help with much except the very worst. Any insight is greatly appreciated! A dose of the original form lasts about 4 hours in your body. Take it with food. The Vyvanse duration or length of time it stays in the system will vary between 10 and 12 hours. I'm almost considering retreating to adderal, as that has been the only pill that has always worked whenever I've used it. Thanks! I can tell it is working to some extent because of the great disruption in my sleep cycle it's been causing however. Other than the afternoon dose being too low and often forgetting the second afternoon dose, it's working better than the Rit. I had the EXACT experience. Keep Vyvanse in a safe place to prevent misuse and abuse. The half-life of Vyvanse in acidic urine can drop to just 8 hours, whereas its half-life in alkaline (high pH) urine can increase between 16 and 31 hours. Eating lunch even though I am not hungry has a positive effect on duration. Vyvanse works very effectively for me, dramatic increase in attention and productivity. I made a nice strong tea after making this post to take advantage of the synergy with caffeine and it definitely helped. Especially when on stimulant medication. I find my crash often coincides with whether or not I have continued to eat throughout the day. You need a minimum of 6 hours, and that's still not enough. Could you clarify a bit, please? Both drugs have a very similar side effect profile. Vyvanse is the quintessential example of a "pro-drug"—an inactive substance that becomes active only after it is absorbed and then metabolized in the body to give the parent drug (4,5). She's worried about my taking stimulants when I'm dealing with constant pain from cervical injury (car accident). In patients with severe renal impairment (GFR 15 to < 30 mL/min/1.73 m2), the maximum dose should not exceed 50 mg/day. I had also been in the habit of taking vyvanse only on the days I thought I needed it. Took that at 4, helped my get through my late-night engineering homework/studying without destroying my sleep. Overall I have been very happy with how Vyvanse has helped me perform. Amphetamine is comprised of a phenethylamine core featuring a phenyl ring bound to an amino (NH2) group through an ethyl chain with an additional methyl substitution at Rα. Selling or giving away Vyvanse may harm others and is against the law. I can usually have a light lunch/snack, but that's it until dinner. Pdoc just switched me from Ritalin to Focalin - ER in the morning, IR in the afternoon. Stu asked. I'm at the very end of my semester, the lectures are coming to an end. Obviously, Vyvanse is a pro-drug that must be absorbed in the small intestine by the PEPT-1 carrier enzyme. Vyvanse may just last longer, both may increase unwanted side effects. Vyvanse is doing a sinister, life-killing thing for me. Vyvanse is taken as a once-daily oral medication in the morning. I have taken Vyvanse on both an empty stomach or right after breakfast. I do experience a crash in the evening, the duration approximately 8-10 hours depending on the day. Press question mark to learn the rest of the keyboard shortcuts. Adderall: First dose on awakening; additional doses (1 or 2) at intervals of 4 to 6 hours. Vyvanse doesn’t focus me quickly and makes me less sociable, where the Dex in the morning is the opposite. In clinical studies designed to measure duration of effect, VYVANSE provided significant efficacy compared to placebo for a full treatment day, up through and including 6:00 pm. No orange juice, pop, etc in the morning! I began Vyvanse at 20 mg per day and it was giving me a good boost - concentration and motivation, my studies went well, better than without the med. However, Vyvanse has an active component, dextroamphetamine, that has a half-life of 12 hours and will remain in your system for around 60 hours. Also, when it is working well, you really shouldn't "feel" it. I just wanted to bring up a topic that is rarely discussed here. Do you take your Vyvanse on an empty stomach or with food? So, this means the symptoms of ADHD are only under control within these hours, and it will eventually wear off. Oddly enough, this was the first day I've had breakfast in a while yet I've never crashed like this until today. Summary. Vyvanse is a medication that doctors prescribe to treat attention deficit hyperactivity disorder or binge eating disorder. Expect the same crash. I hope you are having a good day as you read this thread. Like I've really been putting forward the effort to get my shit together like I never did before. The d-amphetamine in vyvanse is neutralized by acidic environments, ... That means too much acid lowers the dose your body actually absorbs and shortens the duration, those effects combined with the tolerance that naturally develops from repeated use …